2022年8月29日月曜日
世界に数十億人のイミュノドープド（Immunodoped）爆誕！（爆ｗｗｗｗｗｗｗ
2022年8月29日月曜日
新型コロナワクチン接種者は免疫システムを酷使しすぎ。でももうどうにもならない とめられない。（爆ｗhttps://tokumei10.blogspot.com/2022/08/blog-post_460.html
2022年8月30日火曜日
英国本流研究者陣による抗原原罪論文https://t.co/wR9OYV5ewO
— J Sato (@j_sato) August 30, 2022
・武漢株💉3回→前期株への反応高くオミ株への反応低い。T細胞も4割が無反応。既感染の方がT細胞無反応率高く、ハイブリッド免疫は嘘
・武漢株💉3回してオミ株感染→オミ株免疫が持続しない。💉3回者が多いとリピ感染・感染波が長期化
Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure
RESULTS
B and T cell recognition and nAb potency were boosted against previous variants of concern (VOCs) in triple-vaccinated HCWs, but this enhanced immunity was attenuated against B.1.1.529 (Omicron) itself. Furthermore, immune imprinting after B.1.1.7 (Alpha) infection resulted in reduced durability of antibody binding against B.1.1.529 (Omicron), and S1 RBD and whole spike VOC binding correlated poorly with live virus nAb potency. Half of triple-vaccinated HCWs showed no T cell response to B.1.1.529 (Omicron) S1 processed antigen, and all showed reduced responses to the B.1.1.529 (Omicron) peptide pool, irrespective of SARS-CoV-2 infection history. Mapping T cell immunity in class II human leukocyte antigen transgenics showed that individual spike mutations could result in loss or gain of T cell epitope recognition, with changes to T cell effector and regulatory programs. Triple-vaccinated, previously infection-naïve individuals infected during the B.1.1.529 (Omicron) wave showed boosted cross-reactive S1 RBD and whole spike binding, live virus nAb potency, and T cell immunity against previous VOCs but less so against B.1.1.529 (Omicron) itself. Immune imprinting from prior Wuhan Hu-1 infection abrogated any enhanced cross-reactive antibody binding, T cell recognition, MBC frequency, or nAb potency after B.1.1.529 (Omicron) infection.CONCLUSION
Vaccine boosting results in distinct, imprinted patterns of hybrid immunity with different combinations of SARS-CoV-2 infection and vaccination. Immune protection is boosted by B.1.1.529 (Omicron) infection in the triple-vaccinated, previously infection-naïve individuals, but this boosting is lost with prior Wuhan Hu-1 imprinting. This “hybrid immune damping” indicates substantial subversion of immune recognition and differential modulation through immune imprinting and may be the reason why the B.1.1.529 (Omicron) wave has been characterized by breakthrough infection and frequent reinfection with relatively preserved protection against severe disease in triple-vaccinated individuals.
https://www.science.org/doi/10.1126/science.abq1841
immune imprinting＝Original Antigenic Sin（抗原原罪）
、、、（爆ｗｗｗｗｗｗｗｗｗｗｗｗｗｗ
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