勇者は真の神から与えられたご加護を自ら捨て去ったのだよ

匿名 さんのコメント...

不活性化型とmRNA型のどちらの方が抗原原罪が遺伝し易いか。個体の獲得免疫は、それだけでは遺伝しない。生殖細胞レベルで遺伝子改変が起きなければ遺伝するはずが無いわな。

mRNA型の場合に遺伝する機序は、以前の記事で話題になった通り。mRNA型の場合には、高濃度でLNPが精巣と卵巣に蓄積するので、高確率で遺伝することでしょう。

では、不活性化型の場合には、どの様な機序で遺伝するか。自然感染の場合と比較にならない量の武漢株に血管中で血液に暴露して、その血液中の武漢株のRNAが生殖細胞に逆転写された場合には、武漢株の蛋白質を生産する能力を持った生殖細胞を通じて遺伝するということは十分にあり得る。問題は、その確率よね。LNPが精巣と卵巣に蓄積する確率よりは、武漢株のRNAそのものが精巣と卵巣に蓄積する確率の方がはるかに小さい様に思うが。

実際はどうか。

2023年3月9日 12:36 

匿名 さんのコメント...

不活性化型のワクチンで抗原原罪が遺伝するなら、インフルエンザの抗原原罪が遺伝している可能性があるということにもなり得るので、結構、興味深いところですね。

2023年3月9日 16:00 

Evolution of immune genes is associated with the Black Death

Published: 19 October 2022

https://www.nature.com/articles/s41586-022-05349-x

Genes protective during the Black Death may now be increasing autoimmune disorders

Will the COVID-19 pandemic change the genes — and health — of future generations?

December 1, 2022

• By Robert H. Shmerling, MD,

  Senior Faculty Editor, Harvard Health Publishing; Editorial Advisory Board Member, Harvard Health Publishing

Most people alive today have witnessed only one pandemic: COVID-19. But pandemics are nothing new; medical historians have documented nearly 20 major pandemics in the last 1,500 years. And while the last several years have been tough, they pale by comparison to the mid-1300s, when the pandemic dubbed the Black Death was raging and those infected usually died.

The Black Death wiped out as much as half the population of Europe, the Middle East, and Africa. Now, scientists are asking whether survivors of that pandemic had a genetic advantage that allowed them to avoid infection, and if so, what lessons might be drawn for survivors of our current pandemic?

Surviving the Black Plague: Happenstance or genes?

Back in the 1300s, people did what they could to avoid infection. That mostly meant trying to separate the sick from the healthy. But there seemed to be a lot of luck involved in who became infected, who lived and who died. The cause of this plague was entirely mysterious to those living through it. Much later, researchers learned that a bacterium, Yersinia pestis, was the cause, most likely spreading from rodents to fleas to humans.

Recently, researchers extracted DNA from the bones of people who perished during the time of the Black Death and compared it to those who survived that pandemic. They found some important differences: survivors were more likely to carry genes that helped their immune systems fight off the infection. So, perhaps surviving the Black Death wasn’t so random after all.

But the researchers also noticed some other remarkable things:

• Infection-fighting genes increased dramatically in the general population within a few generations. A change of this magnitude across a population in such a short time is nearly unheard of.
• People alive today with autoimmune diseases such as rheumatoid arthritis or lupus are more likely to carry those same infection-fighting genes than people without autoimmune disease. It appears that the genes that helped some of our ancestors avoid a dangerous infection in the 1300s now may be a risk factor for autoimmune disorders.

Understanding selective pressure: Evolution’s action arm

An evolutionary process called selective pressure encourages the survival of favorable genes in a population and discourages unfavorable genes. If any living organism survives long enough to pass favorable genes to the next generation, the species benefits by avoiding potential extinction.

A good example of selective pressure is antibiotic resistance. Let’s say you’re treated with an antibiotic for pneumonia caused by bacteria. The antibiotic is intended to kill the bacteria so that you can recover. But a few bacteria may have a mutation or genetic variation that allows them to survive and flourish despite antibiotic treatment.

As their bacterial brethren are wiped out, the resistant ones thrive, multiply, and pass along their genetic information — including genes that determine antibiotic resistance — to later generations of bacteria. In this example, antibiotic treatment applies selective pressure that encourages (selects for) the development of resistant bacteria: great for the bacteria, though bad, of course, if you’re the person with pneumonia.

Selective pressure has led to adaptations like the ability of chameleons to evade predators by changing color; desert plants able to thrive on minimal water; and humans with our large brains, opposable thumbs, and even our ability to digest milk. COVID-19 variants are another good example: mutations allow the coronavirus responsible for our current pandemic to survive despite vaccinations and antiviral treatments.

The Black Death: Advantageous genes and downstream consequences

In people, genetic changes of this sort usually take hundreds of years. The genetic impact of the Black Death was much faster, presumably because the pandemic was so large and killed so many people before they reached reproductive age. Those with favorable genes made up such a large proportion of survivors that the population’s gene pool changed quickly.

Clearly, though, beneficial genes that take hold in a population may come at a price. We don’t yet know why genes that helped protect against the Black Death might increase the risk of autoimmune disease. Possibly they carry instructions for a particularly vigorous immune system that is able to fight off a dangerous infection, but is also imprecise in its attack or prone to overreaction, leading to the friendly fire of autoimmune illness.

An advantage at one time and in a particular place may come at a price for future generations. For example, genes that cause red blood cells to assume a sickle shape help people resist infection with malaria. Inheriting sickle genes from one parent can be protective, but inheriting sickle genes from both parents causes sickle cell anemia, a potentially life-threatening disease on its own.

Will COVID-19 alter the genes of the world’s population?

Considering the story of the Black Death, you might wonder: will the COVID-19 pandemic have a large impact on the genetic makeup of the world's population through selective pressure? Experts believe that’s unlikely. Even though COVID-19 has killed millions of people worldwide, most of its victims were older. Selective pressure is most powerful when applied to a population before the age of reproduction, as described above.

And curiously, some genes associated with the risk of developing severe COVID appear to lower the risk of certain autoimmune diseases. For now, why that might be remains a mystery.

The bottom line

Surviving the Black Death was no small feat, and likely owed more to genetics than anything else. But gene variations good for our ancestors may be far less beneficial now. These new insights into the Black Death and how selective pressure may contribute to future disease could prove useful to our descendants as they face pandemics of their own.

https://www.health.harvard.edu/blog/genes-protective-during-the-black-death-may-now-be-increasing-autoimmune-disorders-202212012859

COVID-19自体は単なる風邪に毛が生えた程度のもんなので問題なし。

 

2023年3月9日木曜日

年齢問わず致死率１００％近いヤバいもんならともかく、健康な子供や赤ん坊を殺さないコウモリに命を与えてるコロナウイルスにワクチン接種なんてとんでもない愚行

https://tokumei10.blogspot.com/2023/03/blog-post_9.html

しかし、そんなもんに対してワクチンなんぞを接種してしまうと大変なことになるんですよ。そしてそれは不可逆的。（爆ｗｗｗｗｗｗ

勇者から生まれてくる子は武漢株特化型免疫システムを装備して生まれてくるが、その対価としてその他の病気に対する免疫は最弱になってしまうんですよ。要するに生まれた時から抗原原罪人。（爆ｗｗｗｗｗｗｗｗｗｗ

 

2022年6月28日火曜日

人類は「自然自己修復機能」搭載型（Homo Superior）と「自己修復機能」アウトソース型（Homo Inferior）に仕分けられた

なあに、「自然自己修復機能」を対価に「自己修復機能」アウトソース型（Homo Inferior）に仕分けられた勇者の皆様はエロいお医者様と優秀な研究者の皆様他、高学歴の本の勇者サマ型に「おまかせ」しとけば大丈夫。 

これからどんどん素晴らしい新しいワクチンと医薬品が開発されてなんとかなるよ、きっと。（爆ｗｗｗｗｗｗｗ

そしておいらのような愚かな「自然自己修復機能」搭載型（Homo Superior）の連中が巣食いの手を拒否しながら苦しみもがきながら無様に死んでいく様をはるか上から高みの見物を決め込めばええ。（爆ｗｗｗｗｗｗ

アウトソース型は今後全ての病や苦痛から医療発展のお陰で解放されるわけだから・・・

http://tokumei10.blogspot.com/2022/06/homo-superiorhomo-inferior.html

で、インフルエンザワクチンでも〇〇〇ワクチンでも同じように・・・（爆ｗｗｗｗｗｗｗｗ

 

2022年10月30日日曜日

自然免疫のみならず免疫記録をワイプアウトして獲得免疫をもダメにし勇者を無防備マンへと変身させる魔法の薬（笑）

https://tokumei10.blogspot.com/2022/10/blog-post_70.html

2022年1月19日水曜日

人間の免疫力あってこそのワクチンが基本中の基本であり、ワクチンあってこその免疫というトンでも発想に基づいたDeath汁集団接種政策

https://tokumei10.blogspot.com/2022/01/death_72.html

2022年9月29日木曜日

ワクチンなんてもんはBCGをも含め例外なくできるだけ接種しない方が良い

https://tokumei10.blogspot.com/2022/09/bcg.html

 

2022年9月28日水曜日

新型コロナワクチンは獲得免疫システムを無駄に強化すると同時に肝心の自然免疫システムを弱体化させる

https://tokumei10.blogspot.com/2022/09/blog-post_687.html

2023年3月9日木曜日

年齢問わず致死率１００％近いヤバいもんならともかく、健康な子供や赤ん坊を殺さないコウモリに命を与えてるコロナウイルスにワクチン接種なんてとんでもない愚行

で、今後人類は確実に・・・

2023年3月3日金曜日

抗原原罪は遺伝するんです

https://tokumei10.blogspot.com/2023/03/blog-post_36.html

の真の意味を思い知らされる事になり信心深い勇者ほど絶望しSAN値が危険レベルに陥るでしょうな。（爆ｗｗｗｗｗｗｗｗｗｗｗｗ

https://tokumei10.blogspot.com/2023/03/blog-post_9.html

、、、（爆ｗｗｗｗｗｗｗｗｗｗｗｗ