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 Effectiveness of mRNA-1273 against infection and COVID-19 hospitalization with SARS-

CoV-2 Omicron subvariants: BA.1, BA.2, BA.2.12.1, BA.4, and BA.5
Authors: Hung Fu Tseng, PhD,1,2 Bradley K. Ackerson, MD,1 Katia J. Bruxvoort, PhD,1,3 Lina S. Sy,
MPH,1 Julia E. Tubert, MPH,1 Gina S. Lee, MPH,1 Jennifer H. Ku, PhD,1 Ana Florea, PhD,1 Yi Luo, PhD,1
Sijia Qiu, MS,1 Soon Kyu Choi, MPH,1 Harpreet S. Takhar, MPH,1 Michael Aragones, MD,1 Yamuna D.
Paila, PhD,4 Scott Chavers, PhD,4 Lei Qian, PhD1
Affiliations:
1Kaiser Permanente Southern California, 100 S Los Robles Ave., Pasadena, CA 91101, USA
2Kaiser Permanente Bernard J. Tyson School of Medicine, 98 S. Los Robles Ave., Pasadena, CA 91101,
USA
3University of Alabama at Birmingham, 1665 University Blvd, Birmingham, AL 35233, USA

4Moderna, Inc., 200 Technology Square, Cambridge, MA 02139,

https://www.medrxiv.org/content/10.1101/2022.09.30.22280573v1.full.pdf

Three Vaccine Doses Increase Infection Risk by Up to 27%, Study Finds

by Will Jones

4 October 2022 7:19 PM

hree doses of the Moderna Covid vaccine increase your risk of Omicron infection by up to 27%, a study has found.

The pre-print study (not yet peer-reviewed) was funded by Moderna itself and partly designed by employees of Moderna as well as involving researchers from Kaiser Permanente in Southern California. The study’s reporting of poor outcomes for the original vaccine may be understood in the context of Moderna now having a ‘bivalent vaccine’ which targets Omicron.

The study used a test-negative case-control design to evaluate the Moderna Covid vaccine’s effectiveness against infection and hospitalisation with Omicron subvariants. It included 30,809 test-positive and 92,427 test-negative individuals aged over 18 years tested during the first half of 2022. Results were adjusted for potential confounders such as age, sex and comorbidities.

The study found negative effectiveness (i.e., where the vaccinated have a higher infection rate than the unvaccinated) for three doses against all Omicron subvariants (BA.2, BA.2.12.1, BA.4 and BA.5) except BA.1, where the waning was slower.

Vaccine effectiveness against infection was negative within five months (150 days) at around minus-25%, meaning there were 25% more infections in the vaccinated than in the unvaccinated. The results are shown below and I’ve marked the five-month figures in red. The lowest figure was for BA.2.12.1 at nearly minus-27%.It’s worth noting that a recent study from Oxford University found a similar negative vaccine effectiveness pre-Omicron in England data.

Why the picture of the vaccines we are gaining from studies isn’t always consistent is not really clear. However, what is clear is that a number of studies are now showing negative effectiveness, including studies from the manufacturers and pharmaceutical companies themselves. This is worrying as it raises questions of what may be causing it (assuming it is a real phenomenon and not an artefact of some kind). Is it due to immune imprinting (‘original antigenic sin’) impeding the response to later variants, or a more general inhibition of the immune system, or something else? Whatever it is, it is highly disturbing to think that the vaccines may increase susceptibility to infection, and even more disturbing to think that the official solution put forward to address this problem is an endless series of further vaccine doses.

https://dailysceptic.org/2022/10/04/three-vaccine-doses-increase-infection-risk-by-up-to-27-study-finds/

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