- Article
- Published:
FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation
Abstract
SARS-CoV-2 can cause acute respiratory distress and death in some patients1. Although severe COVID-19 disease is linked to exuberant inflammation, how SARS-CoV-2 triggers inflammation is not understood2. Monocytes and macrophages are sentinel cells that sense invasive infection to form inflammasomes that activate caspase-1 and gasdermin D (GSDMD), leading to inflammatory death (pyroptosis) and release of potent inflammatory mediators3. Here we show that about 6% of blood monocytes in COVID-19 patients are infected with SARS-CoV-2. Monocyte infection depends on uptake of antibody-opsonized virus by Fcγ receptors. Vaccine recipient plasma does not promote antibody-dependent monocyte infection. SARS-CoV-2 begins to replicate in monocytes, but infection is aborted, and infectious virus is not detected in infected monocyte culture supernatants. Instead, infected cells undergo inflammatory cell death (pyroptosis) mediated by activation of NLRP3 and AIM2 inflammasomes, caspase-1 and GSDMD. Moreover, tissue-resident macrophages, but not infected epithelial and endothelial cells, from COVID-19 lung autopsies have activated inflammasomes. These findings taken together suggest that antibody-mediated SARS-CoV-2 uptake by monocytes/macrophages triggers inflammatory cell death that aborts production of infectious virus but causes systemic inflammation that contributes to COVID-19 pathogenesis.
SARS-CoV-2 - Antibody Dependent “Enhancement”
More like inflammation really….
Here's Dr. Fauci agreeing with Dr. Leana Wen and saying what so many have been saying for years:
— Scott Morefield (@SKMorefield) April 10, 2022
"This is not going to be eradicated ... Each individual is going to have to make their [risk] calculation ... We're going to have to live with some degree of virus in the community." pic.twitter.com/iapD3VuhM1
HPとMPがZeroになるまで戦うのだ!勇者の諸君!
「It’s about Saving Lives!」
2022年4月10日日曜日
、、、(爆wwwwwwwwwwwwwwwwww
3 件のコメント:
世界樹の葉はありますよ。
MPは回復できませんがw
ファウチセンセの目が死に過ぎw
勇者には手を合わせ続けるよ、てんきゅ
年末には喪中の葉書が全国を席巻するのかなあ
コメントを投稿