4th Dose COVID mRNA Vaccines’ Immunogenicity & Efficacy Against Omicron VOC
Abstract
BACKGROUND Following the emergence of the Omicron variant of concern, we investigated immunogenicity, efficacy and safety of BNT162b2 or mRNA1273 fourth dose in an open-label, clinical intervention trial.
METHODS Primary end-points were safety and immunogenicity and secondary end-points were vaccine efficacy in preventing SARS-CoV-2 infections and COVID-19 symptomatic disease. The two intervention arms were compared to a matched control group. Eligible participants were healthcare-workers (HCW) vaccinated with three BNT162b2 doses, and whose IgG antibody levels were ≤700 BAU (40-percentile). IgG and neutralizing titers, direct neutralization of live VOCs, and T-cell activation were assessed. All participants were actively screened for SARS-CoV-2 infections on a weekly basis.
RESULTS Of 1050 eligible HCW, 154 and 120 were enrolled to receive BNT162b2 and mRNA1273, respectively, and compared to 426 age-matched controls. Recipients of both vaccine types had a ∼9-10-fold increase in IgG and neutralizing titers within 2 weeks of vaccination and an 8-fold increase in live Omicron VOC neutralization, restoring titers to those measured after the third vaccine dose. Breakthrough infections were common, mostly very mild, yet, with high viral loads. Vaccine efficacy against infection was 30% (95%CI:-9% to 55%) and 11% (95%CI:-43% to +43%) for BNT162b2 and mRNA1273, respectively. Local and systemic adverse reactions were reported in 80% and 40%, respectively.
CONCLUSIONS The fourth COVID-19 mRNA dose restores antibody titers to peak post-third dose titers. Low efficacy in preventing mild or asymptomatic Omicron infections and the infectious potential of breakthrough cases raise the urgency of next generation vaccine development.
https://www.medrxiv.org/content/10.1101/2022.02.15.22270948v1
for BNT162b2 and mRNA1273, respectively. Local and systemic adverse reactions were reported in 80% and 40%, respectively.
Local and systemic adverse reactions were reported in 80% and 40%
Local and systemic adverse reactions were reported in 80% and 40%
Local and systemic adverse reactions were reported in 80% and 40%
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3 件のコメント:
求ム 未ワク血液
団長さん! ヤバいです自分も狙われるかも(違うか)
https://twitter.com/yoko01151/status/1493909162983849988
神の裁きぢゃ。
80%か40%ww
殆ど死んでるじゃん ってなるね、その状態
播種性が出てるからエボラみたいな死にざまなのか
HIVや癌末期のようになるのか
後者ならモルヒネ大活躍だねッ しょーゆーこと
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