2022年1月9日日曜日
海軍五省@タビオの大会議と大筒木所縁の靴下の町
町のキャッチフレーズ
靴下の町（国内トップクラスの生産量に由来。全国生産量の約4割） かぐや姫のまち（町内にある讃岐神社にまつわる伝承に由来 https://tokumei10.blogspot.com/2022/01/blog-post_14.html
かぐや姫は、せめて天に上っていくのだけでもお見送りくださいと言うが翁は泣き伏してしまう。「御心が乱れてしまっている」と見かねたかぐや姫は「この先、恋しい折々に、取り出してご覧ください」と手紙を書き置いた。天人の中の者に持たせた箱があり、それには天の羽衣が、また別の箱には不死の薬が入っている。
Remember・・・
2019年1月30日水曜日
ガン・ビジネス業界に最大の危機到来 「ガン治療は1年以内に確立する」イスラエルの研究者らが発表
「ガン治療は1年以内に確立する」イスラエルの研究者らが発表
「来年にもガンの根治が実現するだろう」
イスラエルの研究チームがこの大胆な発表をし世界を騒がせているようだ。
イスラエル紙『エルサレム・ポスト』が報じている。
新薬の開発を行うイスラエル企業『Accelerated Evolution Biotechnologies（AEBi）』が新しいガン治療法を開発した。
それは『MuTaTo』と呼ばれる治療法で、ペプチドワクチン及びペプチド毒素を合わせたものを用いる。
同社CEOのダン・アリドール氏は「我々は一年でガンを完全に治す方法を提供できる」と言及。
また「副作用は全く、もしくはほとんどないし、市場にある他の治療法よりも遥かに安価で治すことができる」と自信をのぞかせている。A cure for cancer? Israeli scientists say they think they found one
“We believe we will offer in a year's time a complete cure for cancer."
By Maayan Jaffe-Hoffman
January 28, 2019 23:14
A small team of Israeli scientists think they might have found the first complete cure for cancer.
“We believe we will offer in a year’s time a complete cure for cancer,” said Dan Aridor, of a new treatment being developed by his company, Accelerated Evolution Biotechnologies Ltd. (AEBi), which was founded in 2000 in the ITEK incubator in the Weizmann Science Park. AEBi developed the SoAP platform, which provides functional leads to very difficult targets.
“Our cancer cure will be effective from day one, will last a duration of a few weeks and will have no or minimal side-effects at a much lower cost than most other treatments on the market,” Aridor said. “Our solution will be both generic and personal.”
It sounds fantastical, especially considering that an estimated 18.1 million new cancer cases are diagnosed worldwide each year, according to reports by the International Agency for Research on Cancer. Further, every sixth death in the world is due to cancer, making it the second leading cause of death (second only to cardiovascular disease).
Aridor, chairman of the board of AEBi and CEO Dr. Ilan Morad, say their treatment, which they call MuTaTo (multi-target toxin) is essentially on the scale of a cancer antibiotic – a disruption technology of the highest order.
The potentially game-changing anti-cancer drug is based on SoAP technology, which belongs to the phage display group of technologies. It involves the introduction of DNA coding for a protein, such as an antibody, into a bacteriophage – a virus that infects bacteria. That protein is then displayed on the surface of the phage. Researchers can use these protein-displaying phages to screen for interactions with other proteins, DNA sequences and small molecules.
In 2018, a team of scientists won the Nobel Prize for their work on phage display in the directed evolution of new proteins – in particular, for the production of antibody therapeutics.
AEBi is doing something similar but with peptides, compounds of two or more amino acids linked in a chain. According to Morad, peptides have several advantages over antibodies, including that they are smaller, cheaper, and easier to produce and regulate.
When the company first started, Morad said, “We were doing what everyone else was doing, trying to discover individual novel peptides for specific cancers.” But shortly thereafter, Morad and his colleague, Dr. Hanan Itzhaki, decided they wanted to do something bigger.
To get started, Morad said they had to identify why other cancer-killing drugs and treatments don’t work or eventually fail. Then, they found a way to counter that effect.
For starters, most anti-cancer drugs attack a specific target on or in the cancer cell, he explained. Inhibiting the target usually affects a physiological pathway that promotes cancer. Mutations in the targets – or downstream in their physiological pathways – could make the targets not relevant to the cancer nature of the cell, and hence the drug attacking it is rendered ineffective.
In contrast, MuTaTo is using a combination of several cancer-targeting peptides for each cancer cell at the same time, combined with a strong peptide toxin that would kill cancer cells specifically. By using at least three targeting peptides on the same structure with a strong toxin, Morad said, “we made sure that the treatment will not be affected by mutations; cancer cells can mutate in such a way that targeted receptors are dropped by the cancer.”
“The probability of having multiple mutations that would modify all targeted receptors simultaneously decreases dramatically with the number of targets used,” Morad continued. “Instead of attacking receptors one at a time, we attack receptors three at a time – not even cancer can mutate three receptors at the same time.”
Furthermore, many cancer cells activate detoxification mechanisms when in stress from drugs. The cells pump out the drugs or modify them to be non-functional. But Morad said detoxification takes time. When the toxin is strong, it has a high probability of killing the cancer cell before detoxification occurs, which is what he is banking on.
Many cytotoxic anticancer treatments aim at fast-growing cells. But cancer stem cells are not fast growing, and they can escape these treatments. Then, when the treatment is over, they can generate cancer again.
“If it does not completely annihilate the cancer, the remaining cells can start to get mutations again, and then the cancer comes back, but this time it is drug resistant,” Morad said.
He explained that because cancer cells are born out of mutations that occur in cancer stem cells, most of the overexpressed proteins which are targeted on the cancer cell exist in the cancer stem cells. MuTaTo’s multiple-target attack ensures that they will be destroyed as well.
Finally, some cancer tumors erect shields which create access problems to large molecules, such as antibodies. MuTaTo acts like an octopus or a piece of spaghetti and can sneak into places where other large molecules cannot reach. Morad said the peptide parts of MuTaTo are very small (12 amino acids long) and lack a rigid structure.
“This should make the whole molecule non-immunogenic in most cases and would enable repeated administration of the drug,” he said.
Morad said their discovery could also reduce the sickening side-effects of most cancer treatments, which stem from drug treatments interacting with the wrong or additional targets, or the correct targets but on non-cancerous cells. He said MuTaTo’s having a combination of several highly specific cancer-targeting peptides on one scaffold for each type of cancer cell would increase the specificity to the cancer cell due to the avidity effect. In addition, in most cases, the non-cancer cells that have a protein in common with the cancer cells do not overexpress it.
“This makes a great difference between the two kinds of cells and should decrease the side effects dramatically,” Morad said.
He equated the concept of MuTaTo to the triple drug cocktail that has helped change AIDS from being an automatic death sentence to a chronic – but often manageable – disease.
Today, AIDS patients take protease inhibitors in combination with two other drugs called reverse transcriptase inhibitors. The drug combination disrupts HIV at different stages in its replication, restrains an enzyme crucial to an early stage of HIV duplication and holds back another enzyme that functions near the end of the HIV replication process.
“We used to give AIDS patients several drugs, but we would administer them one at a time,” Morad explained. “During the course of treatment, the virus mutated, and the AIDS started attacking again. Only when patients started using a cocktail, were they able to stop the disease.”
Now, he said, people with AIDS are HIV carriers, but they are not sick anymore.
The MuTaTo cancer treatment will eventually be personalized. Each patient will provide a piece of his biopsy to the lab, which would then analyze it to know which receptors are overexpressed. The individual would then be administered exactly the molecule cocktail needed to cure his disease.
However, unlike in the case of AIDS, where patients must take the cocktail throughout their lives, in the case of MuTaTo, the cells would be killed, and the patient could likely stop treatment after only a few weeks.
The company is now writing patents on specific peptides, which will be a large bank of targeting toxin peptides wholly owned and hard to break, said Aridor.
Morad said that so far, the company has concluded its first exploratory mice experiment, which inhibited human cancer cell growth and had no effect at all on healthy mice cells, in addition to several in-vitro trials. AEBi is on the cusp of beginning a round of clinical trials which could be completed within a few years and would make the treatment available in specific cases.
Aridor added: “Our results are consistent and repeatable.”
https://www.jpost.com/HEALTH-SCIENCE/A-cure-for-cancer-Israeli-scientists-say-they-think-they-found-one-578939
もしそうなったら今上が全力プッシュしてるガン・ビジネス業界が壊滅状態に陥り、特定の反イスラエル勢力が破綻しますなあ・・・（爆ｗｗｗｗｗｗ
2012年1月25日水曜日
がん治療ビジネスの広告塔に成り下がった天皇皇后両陛下
http://tokumei10.blogspot.com/2012/01/blog-post_25.html
2018年4月15日日曜日
米国に攻撃された施設は「がん研究所」
シリア国営メディア、米国に攻撃された施設は「がん研究所」と反論
http://tokumei10.blogspot.com/2018/04/blog-post_71.html
2011年2月27日日曜日
がん免疫細胞療法と暴力団
http://tokumei10.blogspot.com/2011/02/blog-post_27.html
、、、（爆ｗｗｗｗｗｗｗ
誰も人間のガンだけとは言ってない。（爆ｗｗｗｗｗｗｗｗｗ
医という立場から現代社会の病理を書いた本。あまりにも淡々と本質をえぐりだす語り口は、読んでいて少々暗くなる。 生殖医療について著者は、「わたしたちの手におえ ...
人類は地球の癌か : 医学随想. 藤倉一郎著. 近代文藝社, 2010.2. Title Transcription. ジンルイ ワ チキュウ ノ ガン カ : イガク ズイソウ ...
人類は地球の癌か医学について生殖医療と人口問題長寿について健康とは何か死についての断章医者の信頼について医学教育に何を望むか老いについての諸問題現代社会の ...
健康、長寿、老い、死、先端医療。医学にかかわる人間の未来を考える。
医学随想 人類は地球の癌か [単行本]の通販ならヨドバシカメラの公式サイト「ヨドバシ.com」で！レビュー、Q&A、画像も盛り沢山。ご購入でゴールドポイント取得！
140円 特別天然記念物 オオサンショウウオの絶滅 人類こそ地球の癌細胞／白人の東洋への回帰／饗庭義久(著者) 本、雑誌、コミック 理学、工学 生物学 動物学一般.
2022年1月11日火曜日
そろそろ目標達成かな・・・（爆ｗｗｗｗｗｗｗｗｗｗ
2022年1月10日月曜日
BMI25以上の食らイストの分布図
https://tokumei10.blogspot.com/2022/01/bmi25.html
、、、（爆ｗｗｗｗｗｗｗｗｗｗｗｗｗｗ
5 件のコメント:
癌が問題じゃなくて、癌患者に「治療」と称して群がるユダヒーラー一派が一番の癌
そして、癌の根治以前に、コロナワクチンの副作用による免疫不全であらゆる病気でおっ死ぬ方々ががが
怖いこと書きますねｗ
誰も人間のガンだけとは言ってない＞人類は地球の癌＞今上が全力プッシュしてるガン・ビジネス
こわいこわいｗ
団長のアニメセンスが良すぎる件
細胞がガン化する前に
細胞免疫自体を破壊してしまうということですね
まさに根治wwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwww
というか
おなじみ石原プロモーション張りの
爆破シーンwwwwwwwwwwwwwwwwwwwww
人間は地球を自然を好きだというが
地球は自然はお前らのこと嫌いなんだよ
嫌われない努力をしないﾔﾂとお互い様、共生なんて成立しない
癌でしかないのは当然Deathｯ
>副作用は全く、もしくはほとんどないし、市場にある他の治療法よりも遥かに安価で治すことができる
効果のある治療って大概コレなんだよね
信号機、コンビニ、美容室並みに医療機関が山ほどあるのはおかしい
安価だと経営が成り立ちにくいから処方しない
反イスラエルの特定は日本国内の診療機関の多さと合致するでしょうから
胡蝶蘭で飾られた診療所、特定機能病院になくなってくれるんでしょうね やっほーぃ
コメントを投稿