勇者こと抗原原罪人に朗報！ ブースターの継続的追加接種（アップデート）により抗原原罪の軽減が可能かもしれないアルね！

プレプリントの世界では、抗原原罪があるかないかの議論ではなくて、武漢株💉で埋め込まれた抗原原罪をどうやって解消できるかが実験されている。 https://t.co/vtUGtHmP6e

— J Sato (@j_sato) May 5, 2023

Sharing our latest work on SARS-CoV-2 immune imprinting.
Main finding:
Repeated Omicron infection/boosting alleviates WT vaccine-induced immune imprinting by generating many potent XBB-neutralizing Omicron-specific antibodies that target new RBD epitopes.https://t.co/cqWNisbp3u

— Yunlong Richard Cao (@yunlong_cao) May 3, 2023

 そんなことより・・・

実は中国が抗原原罪人大国であり非常にヤバい状況だという機密情報を安易に漏らして良いアルか？
キンぺーちゃんの許可はちゃんと取ったアルか？（爆ｗｗｗｗｗｗｗｗｗｗｗｗｗｗｗ

 

 

New Results Follow this preprint

Repeated Omicron infection alleviates SARS-CoV-2 immune imprinting

Ayijiang Yisimayi, Weiliang Song, Jing Wang, Fanchong Jian, Yuanling Yu, Xiaosu Chen, Yanli Xu, Sijie Yang, Xiao Niu, Tianhe Xiao, Jing Wang, Ran An, Na Zhang, Yao Wang, Peng Wang, Lijuan Zhao, Haiyan Sun, Lingling Yu, Qingqing Gu, Fei Shao, Ronghua Jin, Zhongyang Shen, Xiaoliang Sunney Xie, Youchun Wang, Yunlong Cao

doi: https://doi.org/10.1101/2023.05.01.538516

This article is a preprint and has not been certified by peer review

Abstract

The continuous emergence of highly immune evasive SARS-CoV-2 variants, like XBB.1.5 and XBB.1.16, highlights the need to update COVID-19 vaccine compositions. However, immune imprinting induced by wildtype (WT)-based vaccination would compromise the antibody response to Omicron-based boosters. Vaccination strategies that can counter immune imprinting are critically needed. In this study, we investigated the degree and dynamics of immune imprinting in mouse models and human cohorts, especially focusing on the role of repeated Omicron stimulation. Our results show that in mice, the efficacy of single Omicron-boosting is heavily limited by immune imprinting, especially when using variants antigenically distinct from WT, like XBB, while the concerning situation could be largely mitigated by a second Omicron booster. Similarly, in humans, we found that repeated Omicron infections could also alleviate WT-vaccination-induced immune imprinting and generate high neutralizing titers against XBB.1.5 and XBB.1.16 in both plasma and nasal mucosa. By isolating 781 RBD-targeting mAbs from repeated Omicron infection cohorts, we revealed that double Omicron exposure alleviates immune imprinting by generating a large proportion of highly matured and potent Omicron-specific antibodies. Importantly, epitope characterization using deep mutational scanning (DMS) showed that these Omicron-specific antibodies target distinct RBD epitopes compared to WT-induced antibodies, and the bias towards non-neutralizing epitopes observed in single Omicron exposures due to imprinting was largely restored after repeated Omicron stimulation, together leading to a substantial neutralizing epitope shift. Based on the DMS profiles, we identified evolution hotspots of XBB.1.5 RBD and demonstrated the combinations of these mutations could further boost XBB.1.5's immune-evasion capability while maintaining high ACE2 binding affinity. Our findings suggest the WT component should be abandoned when updating COVID-19 vaccine antigen compositions to XBB lineages, and those who haven't been exposed to Omicron yet should receive two updated vaccine boosters.

Competing Interest Statement

X.S.X. and Y.C. are inventors on the provisional patent applications of BD series antibodies, which include BD55-5514 (SA55) and mAbs from Omicron infection convalescents. X.S.X. and Y.C. are founders of Singlomics Biopharmaceuticals. Other authors declare no competing interests.

https://www.biorxiv.org/content/10.1101/2023.05.01.538516v2

2023年1月3日火曜日

日本になんぞに真の抗原原罪大国世界一の座は譲らないアルね！

https://tokumei10.blogspot.com/2023/01/blog-post_83.html

2023年3月9日木曜日

遺伝子的に魔改造されたウイルスにおいては不活化ワクチンの方がｍRNAワクチンより実はヤバいあるね。（爆ｗｗｗｗｗｗｗｗ

http://tokumei10.blogspot.com/2023/03/rna.html

2023年4月25日火曜日

あいやー！またアルか！十億人の雑魚勇者による鉄壁の「0の盾」アル！（爆ｗｗｗｗｗ

https://tokumei10.blogspot.com/2023/04/0_25.html

2023年2月6日月曜日

抗原原罪で武漢株砲を無駄に打ちまくる免疫システムアルね

https://tokumei10.blogspot.com/2023/02/blog-post_6.html

2021年12月13日月曜日

抗原原罪（OAS）はｍRNAワクチンのみならずAZ等ウイルスベクター系やシノバックやスプートニックV等不活性化ワクチンでも発生する

http://tokumei10.blogspot.com/2021/12/oasrnaazv.html

とりあえず抗原原罪人に希望の光ある！

抗原原罪人は

オミクロンブースターを打つある

継続してオミクロンブースターを何回でも打ちアップデートし続けるある

死ぬまで打ち続けるある！

site://tokumei10.blogspot.com 抗原原罪

site://tokumei10.blogspot.com 抗原原罪

site://tokumei10.blogspot.com 抗原原罪

site://tokumei10.blogspot.com アップデート

site://tokumei10.blogspot.com アップデート

site://tokumei10.blogspot.com アップデート

2023年4月6日木曜日

勇者たる者は最低でも三か月に一回はアップデートし続けるべしとの統計結果

http://tokumei10.blogspot.com/2023/04/blog-post_9.html

 

2023年4月6日木曜日

人様の米蘭でワクチンマンセー活動に勤しみながらも五回目を接種してない非常に残念な雑魚勇者はウンコ以下の駄々洩れビチグソマウスである

https://tokumei10.blogspot.com/2023/04/blog-post_72.html

2023年3月26日日曜日

勇者の皆様の免疫システム維持のためには年4回から６回のアップデートが必須かもしれない件

http://tokumei10.blogspot.com/2023/03/no4.html

、、、（爆ｗｗｗｗｗｗｗｗｗｗｗｗ