UK reports 223 COVID-19 deaths, most since March | Reuters 1 時間前 — Britain on Tuesday reported 223 deaths within 28 days of a positive test for COVID-19, ... A total of 43,738 new cases were also registered.
The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice Elizabeth M. Rhea, Aric F. Logsdon, […]Michelle A. Erickson
Abstract It is unclear whether severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019, can enter the brain. Severe acute respiratory syndrome coronavirus 2 binds to cells via the S1 subunit of its spike protein. We show that intravenously injected radioiodinated S1 (I-S1) readily crossed the blood–brain barrier in male mice, was taken up by brain regions and entered the parenchymal brain space. I-S1 was also taken up by the lung, spleen, kidney and liver. Intranasally administered I-S1 also entered the brain, although at levels roughly ten times lower than after intravenous administration. APOE genotype and sex did not affect whole-brain I-S1 uptake but had variable effects on uptake by the olfactory bulb, liver, spleen and kidney. I-S1 uptake in the hippocampus and olfactory bulb was reduced by lipopolysaccharide-induced inflammation. Mechanistic studies indicated that I-S1 crosses the blood–brain barrier by adsorptive transcytosis and that murine angiotensin-converting enzyme 2 is involved in brain and lung uptake, but not in kidney, liver or spleen uptake.
COVID-19 RNA Based Vaccines and the Risk of Prion Disease J. Bart Classen, MD*
ABSTRACT Development of new vaccine technology has been plagued with problems in the past. The current RNA based SARS- CoV-2 vaccines were approved in the US using an emergency order without extensive long term safety testing. In this paper the Pfizer COVID-19 vaccine was evaluated for the potential to induce prion-based disease in vaccine recipients. The RNA sequence of the vaccine as well as the spike protein target interaction were analyzed for the potential to convert intracellular RNA binding proteins TAR DNA binding protein (TDP-43) and Fused in Sarcoma (FUS) into their pathologic prion conformations. The results indicate that the vaccine RNA has specific sequences that may induce TDP-43 and FUS to fold into their pathologic prion confirmations. In the current analysis a total of sixteen UG tandem repeats (ΨGΨG) were identified and additional UG (ΨG) rich sequences were identified. Two GGΨA sequences were found. Potential G Quadruplex sequences are possibly present but a more sophisticated computer program is needed to verify these. Furthermore, the spike protein, created by the translation of the vaccine RNA, binds angiotensin converting enzyme 2 (ACE2), a zinc containing enzyme. This interaction has the potential to increase intracellular zinc. Zinc ions have been shown to cause the transformation of TDP-43 to its pathologic prion configuration. The folding of TDP-43 and FUS into their pathologic prion confirmations is known to cause ALS, front temporal lobar degeneration, Alzheimer’s disease and other neurological degenerative diseases. The enclosed finding as well as additional potential risks leads the author to believe that regulatory approval of the RNA based vaccines for SARS-CoV-2 was premature and that the vaccine may cause much more harm than benefit.
8 件のコメント:
> 論理的リスク計算能力及び危機回避能力の欠如
・・・だからうっちゃったのか
うったからそうなっちゃったのかｗｗｗ
UK reports 223 COVID-19 deaths, most since March | Reuters
1 時間前 — Britain on Tuesday reported 223 deaths within 28 days of a positive test for COVID-19, ... A total of 43,738 new cases were also registered.
まるでおバカ製造機じゃないですか
2021年10月20日 1:46
もともと自分で悩むことすらしたくないという
おバカな人が打っているので
むしろ「おバカ加速装置」では
ｗ
ある肌の色の人が一般的に欠如しているなんて事実は、もしあるなら、隠した方がいいですねw
SARS-Cov-2のスパイク蛋白質
脳に入り込んでしまうま(苦笑
症状に頭痛や目眩やらある訳で
一般の風邪ウイルスでも頭痛や不正脈アリ
ウイルス性脳炎や心筋炎起こすんだし当然な
https://www.nature.com/articles/s41593-020-00771-8
The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice
Elizabeth M. Rhea, Aric F. Logsdon, […]Michelle A. Erickson
Abstract
It is unclear whether severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019, can enter the brain. Severe acute respiratory syndrome coronavirus 2 binds to cells via the S1 subunit of its spike protein. We show that intravenously injected radioiodinated S1 (I-S1) readily crossed the blood–brain barrier in male mice, was taken up by brain regions and entered the parenchymal brain space. I-S1 was also taken up by the lung, spleen, kidney and liver. Intranasally administered I-S1 also entered the brain, although at levels roughly ten times lower than after intravenous administration. APOE genotype and sex did not affect whole-brain I-S1 uptake but had variable effects on uptake by the olfactory bulb, liver, spleen and kidney. I-S1 uptake in the hippocampus and olfactory bulb was reduced by lipopolysaccharide-induced inflammation. Mechanistic studies indicated that I-S1 crosses the blood–brain barrier by adsorptive transcytosis and that murine angiotensin-converting enzyme 2 is involved in brain and lung uptake, but not in kidney, liver or spleen uptake.
その上にワザワザmRNA打ち込めば
まあ脳機能低下を来す可能性が高まり
タイトルに掛かる研究はこれですね(苦
https://www.hennessysview.com/images/covid19-rna-based-vaccines-and-the-risk-of-prion-disease-1503.pdf
COVID-19 RNA Based Vaccines and the Risk of Prion Disease
J. Bart Classen, MD*
ABSTRACT
Development of new vaccine technology has been plagued with problems in the past. The current RNA based SARS- CoV-2 vaccines were approved in the US using an emergency order without extensive long term safety testing. In this paper the Pfizer COVID-19 vaccine was evaluated for the potential to induce prion-based disease in vaccine recipients. The RNA sequence of the vaccine as well as the spike protein target interaction were analyzed for the potential to convert intracellular RNA binding proteins TAR DNA binding protein (TDP-43) and Fused in Sarcoma (FUS) into their pathologic prion conformations. The results indicate that the vaccine RNA has specific sequences that may induce TDP-43 and FUS to fold into their pathologic prion confirmations. In the current analysis a total of sixteen UG tandem repeats (ΨGΨG) were identified and additional UG (ΨG) rich sequences were identified. Two GGΨA sequences were found. Potential G Quadruplex sequences are possibly present but a more sophisticated computer program is needed to verify these. Furthermore, the spike protein, created by the translation of the vaccine RNA, binds angiotensin converting enzyme 2 (ACE2), a zinc containing enzyme. This interaction has the potential to increase intracellular zinc. Zinc ions have been shown to cause the transformation of TDP-43 to its pathologic prion configuration. The folding of TDP-43 and FUS into their pathologic prion confirmations is known to cause ALS, front temporal lobar degeneration, Alzheimer’s disease and other neurological degenerative diseases. The enclosed finding as well as additional potential risks leads the author to believe that regulatory approval of the RNA based vaccines for SARS-CoV-2 was premature and that the vaccine may cause much more harm than benefit.
ディップの新型コロナウイルス接種支援「ワクチンインセンティブ」dip ディップ株式会社ワクチン接種であなたを守りたい。プロジェクトアンバサダー 大迫 傑さん
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8月の大会で現役選手としてのラストレースを終えたマラソンランナーの大迫傑さんが、 ディップが掲げるワクチンインセンティブプロジェクトのアンバサダーとして応援してくれています。
☆コロナ禍で職を失い食べていけない人に⦿公園でお弁当配っているようだが、
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https://twitter.com/K9FCR/status/1449751916137762816
20歳の方が心筋炎を発症して、その後、心肺停止から脳死になってしまったのも「後遺症あり」の記載
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