抗原原罪（original antigenic sin）の呪いがｍRNAワクチン以外の新型コロナワクチンでも発生してるっぽい件

 

2021年9月21日火曜日

ｍRNAワクチン接種由来の抗原原罪（こうげんげんざい original antigenic sin）が既に発生してる

https://tokumei10.blogspot.com/2021/09/rna-original-antigenic-sin.html

だから免疫系のウイルスにワクチンはご法度だと・・・（爆ｗｗｗｗｗｗｗｗｗ

Epub 2021 Jun 29.

Is 'original antigenic sin' complicating indian vaccination drive against Covid-19?

Vipin M Vashishtha 1

PMID: 34185632

 

PMCID: PMC8437463

 

DOI: 10.1080/21645515.2021.1945904

Free PMC article

Abstract

India is in the grip of a devastating second wave of Covid-19. Many experts believe new variants of concern (VOC) are behind this unprecedented surge. Some media reports are hinting toward higher risk of Covid infection following Covid vaccinations. 'Original antigenic sin,' in which a prior exposure to an antigen leads to an ineffective response to a related antigen, may offer one immunological explanation for this unusual association. There is an urgent need of undertaking a detailed study to prove/disprove this association.

Keywords: Covid-19; original antigenic sin; vaccines.

https://pubmed.ncbi.nlm.nih.gov/34185632/

Original Antigenic Sin: the Downside of Immunological Memory and Implications for COVID-19

Eric L Brown 1, Heather T Essigmann 2

Affiliations 

• PMID: 33692194
 
• DOI: 10.1128/mSphere.00056-21

Free article

Abstract

The concept of original antigenic sin (OAS) was put forth many years ago to explain how humoral memory responses generated against one set of antigens can affect the nature of antibody responses elicited to challenge infections or vaccinations containing a similar but not identical array of antigens. Here, we highlight the link between OAS and the germinal center reaction (GCR), a process unique to activated B cells undergoing somatic hypermutation and class switch recombination. It is the powerful response of activated memory B cells and the accompanying GCR that establish the foundations of OAS. We apply these concepts to the current COVID-19 pandemic and put forth several possible scenarios whereby OAS may result in either beneficial or harmful outcomes depending, hypothetically, on prior exposure to antigens shared between SARS-CoV-2 and seasonal human coronaviruses (hCoVs) that include betacoronaviruses (e.g., HCoV-OC43 and HCoV-HKU1) and alphacoronaviruses (e.g., HCoV-NL63 and HCoV-HKU1) (E. M. Anderson, E. C. Goodwin, A. Verma, C. P. Arevalo, et al., medRxiv, 2020, https://doi.org/10.1101/2020.11.06.20227215; S. M. Kissler, C. Tedijanto, E. Goldstein, Y. H. Grad, and M. Lipsitch, Science 368:860-868, 2020, https://doi.org/10.1126/science.abb5793).

Keywords: B cells; COVID-19; affinity maturation; germinal center; germinal center reaction; humoral immunity; immunity; imprinting; memory responses; original antigenic sin; vaccines.

https://pubmed.ncbi.nlm.nih.gov/33692194/

徹底したロックダウンにより自然に対新型コロナ免疫をゲットした国民がほとんどいないのにワクチンを打ちまくった宗主国様もアウトかもね。（爆ｗｗｗｗｗｗｗｗ