華南理工大学 武漢キメラウイルスは武漢の研究所から漏れたとの見解

どうやら

武漢ウイルス＝中国製バイオ兵器の武漢キメラウイルス

説確定のようですな。
なんせ北京からのConfirmationですから。
北京のどの勢力かはまだ未確認ですが一応政府公認ですな。

Did coronavirus originate in Chinese government laboratory? Scientists believe killer disease may have begun in research facility 300 yards from Wuhan wet fish market

Beijing-sponsored South China University of Technology concludes that 'the killer coronavirus probably originated from a laboratory in Wuhan'
It points to research on bats and respiratory diseases carried by the animals at the Wuhan Center for Disease Control and the Wuhan Institute of Virology
WCDC is just 300 yards from the seafood market and is adjacent to the hospital

By Ross Ibbetson For Mailonline

Published: 08:22 EST, 16 February 2020 | Updated: 11:00 EST, 16 February 2020
https://www.dailymail.co.uk/news/article-8009669/Did-coronavirus-originate-Chinese-government-laboratory.html

Chinese scientists believe the deadly coronavirus may have started life in a research facility just 300 yards from the Wuhan fish market.

A new bombshell paper from the Beijing-sponsored South China University of Technology says that the Wuhan Center for Disease Control (WHCDC) could have spawned the contagion in Hubei province.

'The possible origins of 2019-nCoV coronavirus,' penned by scholars Botao Xiao and Lei Xiao claims the WHCDC kept disease-ridden animals in laboratories, including 605 bats.

It also mentions that bats - which are linked to coronavirus - once attacked a researcher and 'blood of bat was on his skin.'

And as well as the WHCDC, the report suggests that the Wuhan Institute of Virology could also have leaked the virus, as has previously been reported by MailOnline.

'This laboratory reported that the Chinese horseshoe bats were natural reservoirs for the severe acute respiratory syndrome coronavirus (SARS-CoV) which caused the 2002-3 pandemic,' the report says.

The report says: 'Genome sequences from patients were 96% or 89% identical to the Bat CoV ZC45 coronavirus originally found in Rhinolophus affinis (intermediate horseshoe bat).'

It describes how the only native bats are found around 600 miles away from the Wuhan seafood market and that the probability of bats flying from Yunnan and Zhejiang provinces was minimal.

In addition there is little to suggest the local populace eat the bats as evidenced by testimonies of 31 residents and 28 visitors.

Instead the authors point to research being carried out withing a few hundred yards at the WHCDC.

One of the researchers at the WHCDC described quarantining himself for two weeks after a bat's blood got on his skin, according to the report. That same man also quarantined himself after a bat urinated on him.

華南理工大学（かなんりこうだいがく、South China University of Technology）は、中華人民共和国の広東省広州市にある大学。中華人民共和国教育部直属重点大学、21世紀重点建設大学に指定されている。1952年に設立された、元の名前は華南工学園。前身は1931年設立の国立中山大学理工学部。

中山大学（ちゅうざんだいがく、ピンイン：Zhōngshān Dàxué、英名：Sun Yat-sen University、正しくは「孫逸仙大学」）は、広東省に所在する中華人民共和国の副部級大学である。1924年（民国13年）に創立された。大学の略称は中大（ちゅうだい）又は SYSU。大学は複数の国家重点実験室も持っている。985工程、211工程、双一流の成員校として、国家重点大学である。大学名は孫文の中国革命への貢献に対して敬意を払い、その号である中山を冠して命名された。当初、すべての中山大学は国家主義教育（中山大学モデル）に基づいて採択されました、本学のオリジナルの学生と教員は全員中国国民党党員です。

site://tokumei10.blogspot.com 孫文 神戸

site://tokumei10.blogspot.com 孫文 神戸

site://tokumei10.blogspot.com 孫文 神戸


605 bats、、、（爆ｗｗｗｗｗｗｗｗｗｗ




The possible origins of 2019-nCoV coronavirus
Preprint (PDF Available) · February 2020 with 547 Reads 
DOI: 10.13140/RG.2.2.21799.29601
Cite this publication

Botao Xiao

21.93South China University of Technology

Lei Xiao

Abstract
The 2019-nCoV has caused an epidemic of 28,060 laboratory-confirmed infections in human including 564 deaths in China by February 6, 2020. Two descriptions of the virus published on Nature this week indicated that the genome sequences from patients were almost identical to the Bat CoV ZC45 coronavirus. It was critical to study where the pathogen came from and how it passed onto human. An article published on The Lancet reported that 27 of 41 infected patients were found to have contact with the Huanan Seafood Market in Wuhan. We noted two laboratories conducting research on bat coronavirus in Wuhan, one of which was only 280 meters from the seafood market. We briefly examined the histories of the laboratories and proposed that the coronavirus probably originated from a laboratory. Our proposal provided an alternative origin of the coronavirus in addition to natural recombination and intermediate host.
Discover the world's research

Content uploaded by Botao Xiao
Author content
Content may be subject to copyright.
Download full-text PDF

The possible origins of 2019-nCoV coronavirus
Botao Xiao1,2* and Lei Xiao3

1 Joint International Research Laboratory of Synthetic Biology and Medicine, School
of Biology and Biological Engineering, South China University of Technology,
Guangzhou 510006, China
2 School of Physics, Huazhong University of Science and Technology, Wuhan
430074, China
3 Tian You Hospital, Wuhan University of Science and Technology, Wuhan 430064,
China

* Corresponding author: xiaob@scut.edu.cn
Tel / Fax: 86-20-3938-0631


The 2019-nCoV coronavirus has caused an epidemic of 28,060 laboratory-confirmed
infections in human including 564 deaths in China by February 6, 2020. Two descriptions
of the virus published on Nature this week indicated that the genome sequences from
patients were 96% or 89% identical to the Bat CoV ZC45 coronavirus originally found in
Rhinolophus affinis 1,2. It was critical to study where the pathogen came from and how it
passed onto human.
An article published on The Lancet reported that 41 people in Wuhan were found to
have the acute respiratory syndrome and 27 of them had contact with Huanan Seafood
Market 3. The 2019-nCoV was found in 33 out of 585 samples collected in the market after
the outbreak. The market was suspicious to be the origin of the epidemic, and was shut
down according to the rule of quarantine the source during an epidemic.
The bats carrying CoV ZC45 were originally found in Yunnan or Zhejiang province,
both of which were more than 900 kilometers away from the seafood market. Bats were
normally found to live in caves and trees. But the seafood market is in a densely-populated
district of Wuhan, a metropolitan of ~15 million people. The probability was very low for the
bats to fly to the market. According to municipal reports and the testimonies of 31 residents
and 28 visitors, the bat was never a food source in the city, and no bat was traded in the
market. There was possible natural recombination or intermediate host of the coronavirus,
yet little proof has been reported.
Was there any other possible pathway? We screened the area around the seafood
market and identified two laboratories conducting research on bat coronavirus. Within ~280
meters from the market, there was the Wuhan Center for Disease Control & Prevention
(WHCDC) (Figure 1, from Baidu and Google maps). WHCDC hosted animals in laboratories
for research purpose, one of which was specialized in pathogens collection and identification 4-
6. In one of their studies, 155 bats including Rhinolophus affinis were captured in Hubei
province, and other 450 bats were captured in Zhejiang province 4. The expert in collection
was noted in the Author Contributions (JHT). Moreover, he was broadcasted for collecting
viruses on nation-wide newspapers and websites in 2017 and 2019 7,8. He described that
he was once by attacked by bats and the blood of a bat shot on his skin. He knew the
extreme danger of the infection so he quarantined himself for 14 days 7. In another accident,
he quarantined himself again because bats peed on him. He was once thrilled for capturing
a bat carrying a live tick 8.
Surgery was performed on the caged animals and the tissue samples were collected for
DNA and RNA extraction and sequencing 4, 5. The tissue samples and contaminated trashes
were source of pathogens. They were only ~280 meters from the seafood market. The
WHCDC was also adjacent to the Union Hospital (Figure 1, bottom) where the first group
of doctors were infected during this epidemic. It is plausible that the virus leaked around
and some of them contaminated the initial patients in this epidemic, though solid proofs
are needed in future study.
The second laboratory was ~12 kilometers from the seafood market and belonged to
Wuhan Institute of Virology, Chinese Academy of Sciences 1, 9, 10. This laboratory
reported that the Chinese horseshoe bats were natural reservoirs for the severe acute
respiratory syndrome coronavirus (SARS-CoV) which caused the 2002-3 pandemic 9.
The principle investigator participated in a project which generated a chimeric virus using
the SARS-CoV reverse genetics system, and reported the potential for human
emergence 10. A direct speculation was that SARS-CoV or its derivative might leak from
the laboratory.
In summary, somebody was entangled with the evolution of 2019-nCoV coronavirus.
In addition to origins of natural recombination and intermediate host, the killer coronavirus
probably originated from a laboratory in Wuhan. Safety level may need to be reinforced in
high risk biohazardous laboratories. Regulations may be taken to relocate these
laboratories far away from city center and other densely populated places.


Contributors
BX designed the comment and performed literature search. All authors performed data
acquisition and analysis, collected documents, draw the figure, and wrote the papers.

Acknowledgements
This work is supported by the National Natural Science Foundation of China (11772133,
11372116).

Declaration of interests
All authors declare no competing interests.

References

1. Zhou P, Yang X-L, Wang X-G, et al. A pneumonia outbreak associated with a new
coronavirus of probable bat origin. Nature 2020. https://doi.org/10.1038/s41586-020-2012-7.
2. Wu F, Zhao S, Yu B, et al. A new coronavirus associated with human respiratory disease
in China. Nature 2020. https://doi.org/10.1038/s41586-020-2008-3.
3. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel
coronavirus in Wuhan, China. The Lancet 2019. https://doi.org/10.1016/S0140-
6736(20)30183-5.
4. Guo WP, Lin XD, Wang W, et al. Phylogeny and origins of hantaviruses harbored by bats,
insectivores, and rodents. PLoS pathogens 2013; 9(2): e1003159.
5. Lu M, Tian JH, Yu B, Guo WP, Holmes EC, Zhang YZ. Extensive diversity of rickettsiales
bacteria in ticks from Wuhan, China. Ticks and tick-borne diseases 2017; 8(4): 574-80.
6. Shi M, Lin XD, Chen X, et al. The evolutionary history of vertebrate RNA viruses. Nature
2018; 556(7700): 197-202.
7. Tao P. Expert in Wuhan collected ten thousands animals: capture bats in mountain at night.
Changjiang Times 2017.
8. Li QX, Zhanyao. Playing with elephant dung, fishing for sea bottom mud: the work that will
change China's future. thepaper 2019.
9. Ge XY, Li JL, Yang XL, et al. Isolation and characterization of a bat SARS-like coronavirus
that uses the ACE2 receptor. Nature 2013; 503(7477): 535-8.
10. Menachery VD, Yount BL, Jr., Debbink K, et al. A SARS-like cluster of circulating bat
coronaviruses shows potential for human emergence. Nature medicine 2015; 21(12): 1508-13
https://www.researchgate.net/publication/339070128_The_possible_origins_of_2019-nCoV_coronavirus