実質的にブースター接種によるADE発生確認の無慈悲なお知らせ

 

• Article
• Published: 06 April 2022

FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation

Abstract

SARS-CoV-2 can cause acute respiratory distress and death in some patients¹. Although severe COVID-19 disease is linked to exuberant inflammation, how SARS-CoV-2 triggers inflammation is not understood². Monocytes and macrophages are sentinel cells that sense invasive infection to form inflammasomes that activate caspase-1 and gasdermin D (GSDMD), leading to inflammatory death (pyroptosis) and release of potent inflammatory mediators³. Here we show that about 6% of blood monocytes in COVID-19 patients are infected with SARS-CoV-2. Monocyte infection depends on uptake of antibody-opsonized virus by Fcγ receptors. Vaccine recipient plasma does not promote antibody-dependent monocyte infection. SARS-CoV-2 begins to replicate in monocytes, but infection is aborted, and infectious virus is not detected in infected monocyte culture supernatants. Instead, infected cells undergo inflammatory cell death (pyroptosis) mediated by activation of NLRP3 and AIM2 inflammasomes, caspase-1 and GSDMD. Moreover, tissue-resident macrophages, but not infected epithelial and endothelial cells, from COVID-19 lung autopsies have activated inflammasomes. These findings taken together suggest that antibody-mediated SARS-CoV-2 uptake by monocytes/macrophages triggers inflammatory cell death that aborts production of infectious virus but causes systemic inflammation that contributes to COVID-19 pathogenesis.

https://www.nature.com/articles/s41586-022-04702-4

詳しい説明は・・・

SARS-CoV-2 - Antibody Dependent “Enhancement”

More like inflammation really….

Apr 9

https://worldedge.substack.com/p/sars-cov-2-antibody-dependent-enhancement

辺り参照。

で、実質的にファウチせんせから敗北宣言で今後のコロナ対策は既に抗原原罪（ＯＡＳ）でＨＰとＭＰが低下中の勇者の皆様各々に丸投げ・・・（爆ｗｗｗｗｗｗｗｗｗ

Here's Dr. Fauci agreeing with Dr. Leana Wen and saying what so many have been saying for years:

"This is not going to be eradicated ... Each individual is going to have to make their [risk] calculation ... We're going to have to live with some degree of virus in the community." pic.twitter.com/iapD3VuhM1

— Scott Morefield (@SKMorefield) April 10, 2022

 ＨＰとＭＰがＺｅｒｏになるまで戦うのだ！勇者の諸君！

「Ｉｔ’ｓ　ａｂｏｕｔ　Ｓａｖｉｎｇ　Ｌｉｖｅｓ！」

2022年4月10日日曜日

武漢の真実　コウモリはバクテリアとウイルスまみれだからこそ絶滅しないし天まで飛べるのだよ

https://tokumei10.blogspot.com/2022/04/blog-post_27.html

、、、（爆ｗｗｗｗｗｗｗｗｗｗｗｗｗｗｗｗｗｗ