第一世代ｍRNAワクチンを慌てて接種したら負け（爆ｗｗｗｗｗｗｗｗｗｗ

 

Infection-enhancing anti-SARS-CoV-2 antibodies recognize both the original Wuhan/D614G strain and Delta variants. A potential risk for mass vaccination ?

• Nouara Yahi
• Henri Chahinian
• Jacques Fantini

Published:August 09, 2021DOI:https://doi.org/10.1016/j.jinf.2021.08.010

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In conclusion, ADE may occur in people receiving vaccines based on the original Wuhan strain spike sequence (either mRNA or viral vectors) and then exposed to a Delta variant. Although this potential risk has been cleverly anticipated before the massive use of Covid-19 vaccines

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, the ability of SARS-CoV-2 antibodies to mediate infection enhancement in vivo has never been formally demonstrated. However, although the results obtained so far have been rather reassuring

¹

, to the best of our knowledge ADE of Delta variants has not been specifically assessed. Since our data indicate that Delta variants are especially well recognized by infection enhancing antibodies targeting the NTD, the possibility of ADE should be further investigated as it may represent a potential risk for mass vaccination during the current Delta variant pandemic. In this respect, second generation vaccines7
with spike protein formulations lacking structurally-conserved ADE-related epitopes should be considered.

https://www.journalofinfection.com/article/S0163-4453(21)00392-3/fulltext

→second generation vaccines⁷

で、第一世代ｍRNAワクチンとのコンフリクトは？（爆ｗｗｗｗｗｗｗｗｗｗｗｗｗ